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Our projects


Among the 380000 new cases of patients suffering from cancer per year in France, a great majority of them are treated with radio-chemotherapy and about 5-15% patients may exhibit post- treatment tissue over-reactions (dermatitis, fibrosis, oedema ...) of different severities (grades) that limit the application of the scheduled treatment. Radiosensitivity of normal tissues is therefore needed to decrease morbidity. However, if a dose reduction is applied to spare normal tissues, the anti-cancer treatment efficiency will be not warranted.

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Heavy metals are still abundantly used in a number of industrial activities such as mining and metallurgy. In developed countries, they are also employed in the manufacture of fertilizers, paints, plastics stabilizers, cigarettes and batteries and in recent products such as mobile phones and CD/DVDs


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Nowadays, in order to protect the different types of agricultural cultures from fungi, insects, rodents, bacteria, etc…pesticides are more commonly used for prevention, control or elimination of these undesirable organisms. This abundant use of pesticides contaminate soil and surrounding waters, wildlife and may spread by air to more civilized places. Some pesticides are implicated in the onset of cancer. Hence a growing questioning about the harmful impact of these pesticides on the body (increased risk of cancer) as well as the environment. However, the cellular and molecular basis of toxicity and / or carcinogenicity of pesticides are yet to be determined.


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Industrial activities are responsible for the presence of abundant metallic traces in soils such as Zn, Ni, Pb and Cu and of numerous pesticides like atrazine and thiabendazole. Among the industrial and occupational situations leading to contamination of Cu, the most abundant source is the use of Cu-containing fongicides in vineyards and fruit tree cultures. Since the discovery of the protective action of Cu against wine diseases at the end of XIXth century, the use of products containing Cu has been extended significantly in all the French territories concerned by wine.


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EVAluation of radiation-induced RISk in Exposed workers to ionizing radiation


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The  impact of individual factors in the adaptive response (AR) to Ionizing Radiation.


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ERADIM Project

Study of the breast cancer risk associated with mammographic exposure: Cross radiobiological approach and definition of genetic statuses risk with individual radiation at low doses.

As part of the terms of organized breast cancer screening, genetically predisposed people to this type of cancer (BRCA1 and BRCA2) need a special attention. This results in enhanced surveillance of these patients by mammography. The medical and biological community in charge has strong suspicion about the genetics effects of repeated irradiation on these asymptomatic individuals.

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380000 new cases of cancer are detected every year, most of the time radiotherapy is chosen to cure these cancer. Treatment can be stop or slowing down in 5 to 20% of time because of tissue complication (dermatitis, proctitis). Radiotherapy pioneers have discovered that these tissues reactions are due to individual radiosensitivity. Since 2003, we are solicited to predict and explain these tissues reactions by more than 60 radiotherapists over 30 anticancer centers and hospitals. We expose fibroblast from skin biopsies of patients to a unique dose of 2Gy.

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GRRAAL Project

Gliomas are the most prevalent nervus central system tumors. Glioma radioresistance and high reactions of healthy tissues after radiotherapy, are the reasons why patients survival are really difficult to achieve despite the innovating or standard treatments.

To secure anti-glioma treatment clinical transfer, molecular and cellular studies on gliomas and healthy cerebral tissues will be needed


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70% of cervix cancers, 20% of upper aerodigestives track tumors and 85% of canal anal tumors are due to Human papillomavirus infection (HPV). Despite vaccination, chirurgy and radio-chemotherapy are the classical treatment to cure HPV- cancers. While it is accepted that HPV+ tumors are more radiosentitive, and so easier to cure, the link between HPV infection status and radiation response need further investigation.

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INDIRA project

The general population radiosensibility percentage has been evaluated at 5% and 15% by the International Commission on Radiological Protection (ICRP). To verify this number, we have decided to submit Indira project, knowing the Nuclear Safety Authority, ASN) priority given for research on individual factor. The aim of this study is to determine the radiosensitivity doses seen in case of a nuclear accident sub population in the general population. Thanks to high capacity and quick realization test.

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ARPEGE project

About 900 children and adolescents benefit from radiotherapy (RT) every year in France. The mean age at diagnosis is 5 years; life expectancy for the 80% of them who could cure is long, and the incidence of radiation-related acute and mainly late complications could exceed that of adults, notably because of high incidence of genetic syndromes. The occurrence of radiosensitivity (RS) of healthy tissue in that specific population is still misknown. Screening hypersensitive patients is therefore a major step forward in the management of childhood cancers to personalize RT.

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In order to understand the perceptions of radiotherapy, three social psychology studies were implemented. The first was committed to understanding the social representation of health policy makers face individual radiosensitivity. The second dealt with the same social representation in radiotherapists. The latest study, CLEPSYDRE project, addresses the third part of this problem: the social representation of patients treated with radiotherapy facing individual sensitivity. This problematic includes: the experience of the treatment, quality of life; caregiver-patient relations; secular knowledge.


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CELLINE project

Occasionally, radiation therapy must be modified or abandoned if a patient exhibits acute responses to radiation. In 1981, a correlation between clinical responsiveness (quantified in vivo by tumour local control) and cellular intrinsic radiosensitivity (assessed in vitro by clonogenic assays) has been established. In order to make faster the prediction of the clinical response to radiation, considerable efforts were thereafter provided to develop molecular assays. However,     to collect cells from patients exhibiting acute reactions to their anticancer treatment raises a number of practical issues.

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Un groupe de recherche dépendant de :


Université Claude Bernard Lyon1


Centre Léon Berard

Hopitaux de lyon